This webinar will review the complex relationships between substance misuse and suicide, with a focus on opioid use disorder (OUD) as a category associated with significant elevation of suicide risk and premature mortality. Methodological challenges in detecting drug poisoning suicides will be reviewed along with emerging clinical data that suggest treatment-seeking OUD patients who have survived non-fatal opioid overdose report desire and intention to die prior to overdose along a continuum of severity, suggesting the utility of suicide screening and prevention integrated into routine care of patients with OUD. Presenter: Hillary S. Connery, MD, PhD, Clinical Director Division of Alcohol, Drugs, and Addiction at McLean Hospital Department of Psychiatry, Harvard Medical School