In this Prevention Talk we will address the implications that the changing status of marijuana has for prevention and how prevention science can help us address these issues through family, media and environmental interventions. We will have the opportunity to hear from three renowned researchers and experts in substance use prevention: William Crano, PhD, J. Douglas Coatsworth, PhD., and Mallie J. Paschall, PhD.. Each of them will deliver a brief presentation from their field of research, followed by a discussion led by Zili Sloboda, ScD., APSI's president. Questions from the audience are welcome.