Authors: Felipe Castillo, Mei-Chen Hu, Ying Liu, Raymond R. Balise, Roger D. Weiss, John Rotrosen, Edward V. Nunes, Andrew J. Saxon, Daniel J. Feaster, Sean X. Luo
Patients in treatment with medications for opioid use disorder (MOUD) often report use of other substances in addition to opioids. Few studies exist that examine the relationship between use at treatment entry and early non-opioid use in opioid treatment outcome.
We combined and harmonized three randomized, controlled MOUD clinical trials from the National Institutes of Drug Abuse (NIDA) Clinical Trials Network (CTN) (N=2197) and investigated the association of non-opioid substance use at treatment entry and during early treatment with a return to opioid use.
When treatment cohorts were adjusted, no association between self-reported treatment entry use of non-opioid substances and week-12 opioid use was detected.