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Abtract Abstrak   The faster a drug enters the brain, the greater its addictive potential, yet the brain circuits underlying the rate dependency to drug reward remain unresolved. With simultaneous PET-fMRI we linked dynamics of dopamine signaling, brain activity/connectivity, and self-reported

Abtract Abstrak   IMPORTANCE POIN PENTING   Buprenorphine treatment for opioid use disorder (OUD) has more than doubled since 2009. However, current US Food and Drug Administration buprenorphine dosing guidelines are based on studies among people using heroin, prior to the emergence of fen

Rationale Dasar Pemikiran Xylazine has emerged in recent years as an adulterant in an increasing number of opioid-positive overdose deaths in the United States. Although its exact role in opioid-induced overdose deaths is largely unknown, xylazine is known to depress vital functions and cause hypote

Abtract Abstrak   Drug overdoses from opioids and stimulants are a major cause of mortality in the United States. It is unclear if there are stable sex differences in overdose mortality for these drugs across states, whether these differ across the lifespan, and if so, whether they can be accou

Treatments Used Among Adolescent Residential Addiction Treatment Facilities in the US, 2022 Perawatan Yang Digunakan Pada Fasilitas Pengobatan Adiksi Residensial Bagi Remaja di Amerika Serikat, 2022   An unprecedented number of adolescents were identified as having an opioid use disorder (OUD)

Abtract Abstrak   Introduction Pendahuluan The HIV Prevention Trials Network (HPTN) 074 study demonstrated a positive effect of an integrated systems navigation and psychosocial counseling intervention on HIV treatment initiation, viral suppression, medication assisted treatment (MAT) enrollmen

Hubungan Antara gangguan penggunaan kanabis dan Skizofrenia lebih kuat pada laki-laki muda dibandingkan pada perempuan   Abstract Abstrak   Background. Previous research suggests an increase in schizophrenia population attributable risk fraction (PARF) for cannabis use disorder (CUD). How

IMPORTANCE KEPENTINGAN Recent information on the prevalence of prescription stimulant therapy for attention-deficit/hyperactivity disorder (ADHD) and nonmedical use of prescription stimulants (NUPS) at the school-level among US secondary school students is limited. Informasi terkini mengenai prevale

Abstract Abstrak   Genetic liability to substance use disorders can be parsed into loci that confer general or substance-specific addiction risk. We report a multivariate genome-wide association meta-analysis that disaggregates general and substance-specific loci from published summary statisti

Abtract Abstrak   Background and objective: Tujuan dan Latar Belakang Drug use type and frequency may affect Anti-Retroviral Therapy (ART) uptake for HIV-infected people who inject drugs (PWID). This paper assesses the association between self-reported baseline drug use and ART among HIV-infec

Abtract Abstrak   Internet has become an important part of the daily life of adolescents. Easy access to internet and its social appeal among adolescent males render them at an increased risk of internet addiction and the associated adverse physical and psychosocial effects. We conducted a qual

Introduction Pendahuluan Depression is the most commonly reported neuropsychiatric complication among people living with HIV (PLWH). The prevalence of depression symptoms in people who inject drugs (PWID) is even higher. Depression may negatively affect HIV treatment initiation and adherence and may

Introduction Pendahuluan Despite well-documented benefits of opioid agonist treatment (OAT), there are still many barriers that diminish its potential benefits. Coverage with OAT and needle and syringe programs (NSP) remains poor at the global level, especially in the regions with the largest popula

Introduction Pendahuluan Given concerns about the social risks and ethics of conducting research with people who inject drugs (PWID) who may be affected by HIV it is important to identify not only research-related risks, but also the benefits that may be realized by research participation. These can

INTRODUCTION PENDAHULUAN   Timely engagement in HIV and medication-assisted treatment (MAT) is imperative for PWID to improve health outcomes and prevent ongoing transmission. Novel approaches are needed to design and implement flexible interventions that can be sustainable and tailored to indi

Introduction Pendahuluan Globally, effective HIV prevention interventions are needed to promote antiretroviral therapy (ART) uptake and adherence among people who inject drugs (PWID). Among PWID, treatment as prevention is more complex, due to several issues including primarily blood-borne transmiss

Introduction Pendahuluan   Given the ethical complexity of mitigating stigma and legal risks and providing effective harm reduction services, PWID have been largely excluded from HIV prevention trials]. Although HIV Prevention Trials Network (HPTN) 052 demonstrated the benefit of early antiretr

Summary The study was conducted in three countries with high prevalence of addiction cases: Indonesia, Vietnam, and Ukraine. The aim of the study is to assess the feasibility of a future controlled trial based on the incidence of HIV, enrolment, retention, and uptake of the intervention, and the eff

Introduction Pendahuluan High-risk sharing practices among people who inject drugs (PWID) are associated with high rates of HIV transmission in several parts of the world. PWID in these regions also face significant barriers to HIV testing and engagement in care, highlighting the need to develop and

Introduction Pendahuluan Substance use is likely a major factor in poor HIV clinical outcomes. To improve their health, persons with HIV infection and substance use may require treatment for substance use disorders in concert with HIV treatment. This study wanted to explore the effect of patient nav