This document highlights the challenges faced by pregnant and parenting women (PPW) with opioid use disorder (OUD) and describes approaches to improve their treatment and care. It emphasizes the importance of evidence-based practices, multidisciplinary care teams, harm reduction strategies, and stigma reduction activities. This document is provided by SAMHSA and may be of interest to stakeholders who are focused on improving maternal and child health, addressing opioid use disorder (OUD), and interested in implementing holistic care programs for pregnant and parenting women.